Our publications

Our advice and treatments are always based on the latest medical science. We do not only orientate ourselves on the knowledge of others, but also actively contribute to the research of new techniques and therapy possibilities. In the following you will find a selection of our most important scientific publications.


  1. Meijer H et al.: The production of anti-inflammatory cytokines in whole blood by physico-chemical induction. Inflamm Res (2003) 52(10): 404–407
  2. Baltzer AWA et al: Intraartikuläre Therapie der Gonarthrose mit autologem Interleukin-1 Rezeptor Antagonisten (IL-1Ra). Deutsche Zeitschrift für Sportmedizin (2003) 54(6): 209–211
  1. Wright-Carpenter T et al.: Treatment of muscle injuries by local administration of autologous conditioned serum: animal experiments using a muscle contusion model. Int J Sports Med (2004) 25(8): 582-587
  2. Wright-Carpenter T et al.: Treatment of muscle injuries by local administration of autologous conditioned serum: a pilot study on sportsmen with muscle strains. Int J Sports Med (2004) 25(8): 588–593
  1. Moser C et al.: Die Rolle der Zytokine bei Knorpeldefekten und in der Knorpeltherapie. Interleukin-1 und TNF-a: Schlüsselfaktoren der Knorpeldestruktion. Arthroskopie (2005) 18(3): 181–185
  2. Levy E et al.: Intraartikuläre Behandlung mit autologem irap conditionierten Serum – Teil 1. pferde spiegel 3/2005: 120–124
  3. Hague BA: Clinical Impression of ORTHOKINE (IRAP) Treating Joint Disease in the Performance Horse. ACVS conference 2005, San Diego, USA
  1. Glawe H: ORTHOKIN®-Therapie: Autologes Conditioniertes Serum an der Wirbelsäule. Eine Anwendungsbeobachtung an 261 Patienten. Poster 2006
  2. Theodoridis T, Krämer J: Interleukin-1-Rezeptor-Antagonist-Protein (IRAP). In: Injektionstherapie an der Wirbelsäule. Manual und Atlas, 37-40. Georg Thieme Verlag (2006) ISBN 3-13-141041-8A
  1. Becker C et al.: Efficacy of epidural perineural injections with autologous conditioned serum for lumbar radicular compression: an investigator-initiated, prospective, double-blind, reference-controlled study. Spine (2007) 32(17): 1803–1808
  2. Frisbie DD et al.: Clinical, biochemical, and histologic effects of intra-articular administration of autologous conditioned serum in horses with experimentally induced osteoarthritis. Am J Vet Res (2007) 68(3): 290–296
  3. Wehling P et al.: Autologous Conditioned Serum in the treatment of Orthopaedic diseases – The ORTHOKINE® Therapy. Biodrugs (2007) 21(5): 323–332


  1. Yang KG et al.: Autologous interleukin-1 receptor antagonist improves function and symptoms in osteoarthritis when compared to placebo in a prospective randomized controlled trial. Osteoarthritis and Cartilage (2008) 16(4): 498–505
  2. Österdahl J: Evaluation of autologous conditioned serum. Degree project 2008:67 at Swedish University of Agricultural Sciences, Uppsala (2008) ISSN 1652-8697
  3. Creaney L, Hamilton B: Growth factor delivery methods in the management of sports injuries: the state of play. Br J Sports Med (2008) 42: 314–320
  4. Jöstingmeier U: Vergleichende Betrachtung des Behandlungserfolges der intra-artikulären kombinierten Behandlung mit Natriumhyaluronat und Betamethason mit der intraartikulären Behandlung mit autologem konditionierten Serum (IL-1Ra) bei Pferden mit positiver Hufgelenksanästhesie - Eine Anwendungsbeobachtung. In-augural-Dissertation an der Freien Universität Berlin (2008) ISBN 978-3-86664-665-0
  5. Martinelli MJ et al.: Biochemical Characterization and Clinical Assessment of Autologous Conditioned Serum Treatment in Race Horses. Annual Meeting of the Orthopaedic Research Society 2008, San Francisco, USA
  6. Weinberger T: Klinische Erfahrungen mit der Anwendung von ACS / ORTHOKIN® / IRAP beim Pferd. pferde spiegel 3/2008
  7. Weinberger T.: Clinical experience with ACS/ORTHOKINE/IRAP in horses. Equine Sports Medicine 3/2008
  8. Weinberger T.: Regenerative Therapiemöglichkeiten beim Pferd – eine Übersicht. pferde spiegel 3/2008
  1. Wehling P et al.: Use of Autologous Conditioned Cell-free Serum (ORTHOKINE®) in Treating Osteoarthritis and Sciatic Back Pain. European Musculoskeletal Review (2009) 4(1): 8–11
  2. Majewski M et al.: Accelerated Healing of the Rat Achilles Tendon in Response to Autologous Conditioned Serum. The American Journal of Sports Medicine (2009) 11: 2117–2125
  3. Chevalier X et al.: Intraarticular injection of anakinra in osteoarthritis of the knee: a multicenter, randomized, double-blind, placebo-controlled study. Arthritis & Rheumatism (2009) 61(3): 344–352
  4. Baltzer AWA et al.: Autologous conditioned serum (ORTHOKINE®) is an effective treatment for knee osteoarthritis. Osteoarthritis and Cartilage (2009) 17(2): 152–160
  5. Darabos N et al.: Correlation between synovial fluid and serum IL-1ß levels after ACL surgery - preliminary report. International Orthopedics (SICOT) (2009) 33: 413–418
  1. Fox BA, Stephens MM: Treatment of knee osteoarthritis with ORTHOKINE-derived autologous conditioned serum. Expert Rev Clin Immunol (2010) 6(3): 335–345
  1. Textor J: Autologous biologic treatment for equine musculoskeletal injuries: platelet-rich plasma and IL-1 receptor antagonist protein. Vet Clin North Am Equine Pract. 2011 Aug; 27(2): 275–298. doi: 10.1016/j.cveq.2011.05.001. PubMed PMID: 21872759
  2. Darabos N et al.: Intraarticular application of autologous conditioned serum (ACS) reduces bone tunnel widening after ACL reconstructive surgery in a randomized controlled trial. Knee Surg Sports Traumatol Arthrosc (2011) 19: 36–46
  3. Geburek F, Stadler P: Regenerative therapy for tendon and ligament disorders in horses. Terminology, production, biologic potential and in vitro effects. Tierarztl Prax Ausg G Grosstiere Nutztiere. 2011; 39(6): 373–83. Review. German. PubMed PMID: 22167082
  1. Heisterbach PE et al.: Effect of BMP-12, TGF-β1 and autologous conditioned serum on growth factor expression in Achilles tendon healing. Knee Surg Sports Traumatol Arthrosc (2012) 20(10): 1907–1914
  1. Alvarez-Camino JC et al.: Use of autologous conditioned serum (ORTHOKINE) for the treatment of the degenerative osteoarthritis of the temporomandibular joint. Review of the literature. Med Oral Patol Oral Cir Bucal (2013) 18 (3): 433–438
  2. Frizziero A et al.: Autologous conditioned serum for the treatment of osteoarthritis and other possible applications in musculoskeletal disorders. Br Med Bull (2013) 105: 169–184
  3. Baltzer AWA et al.: A new treatment for hip osteoarthritis: clinical evidence for the efficacy of autologous conditioned serum. Orthop Rev (2013) 5(2):e13
  4. Weisshaar MP, Gaji S: Signaling Proteins (Growth Factors and Cytokines) in Orthopaedics. Comparison of two blood processing techniques: ORTHOKINE® and ACP®. CORS congress 2013 Venice, Italy
  5. Morgenstern DR et al.: Adjunctive Biological Treatment for Degenerative Hip Disease with Focal Chondro Labral Defects. ISHA Annual Meeting, Munich, Poster 58 (2013)
  1. Astolfi M, McGuire K, Kaminski TW: The effectiveness of autologous conditioned serum in the treatment of knee osteoarthritis. J Sport Rehabil. 2014 Nov;23(4):365-9. doi: 10.1123/jsr.2013-0029. Epub 2014 May 2. Review. PubMed PMID: 24810293.
  2. Beyzadeoglu T: Cytokines in Sports Medicine. ISAKOS NEWSLETTER 2014: Volume I. Current Concepts, 1–44.
  3. Majewski M, von Wehren L, & Blanke F: Treatment Of Achillodynia With Local Injections Of Autologous Conditioned Serum (acs). British Journal of Sports Medicine, 48(Suppl_2), A38–A39. http://doi.org/10.1136/bjsports-2014-094114.60
  1. Frisbie DD: Autologous-conditioned serum: evidence for use in the knee. J Knee Surg. 2015 Feb; 28(1):63-6. doi: 10.1055/s-0034-1543956. Epub 2015 Jan 19. PubMed PMID: 25599270
  2. Baselga J et al: Treatment of Osteoarthritis of the Knee with a Combination of Autologous Conditioned Serum and Physiotherapy: A Two-Year Observational Study. PLoS ONE 10(12): e0145551.
  3. Geburek F et al.: Effect of a single injection of autologous conditioned serum (ACS) on tendon healing in equine naturally occurring tendinopathies; Stem Cell Research & Therapy 6:126 (2015)
  4. Torrero JI, Martínez C: New developments in the treatment of osteoarthritis -focus on biologic agents. Open Access Rheumatol. 2015 Jul 22;7:33-43. eCollection 2015. Review. PubMed PMID: 27790043; PubMed Central PMCID: PMC5045124.
  1. Wehling P et al: How does surgery compare with advanced intra-articular therapies in knee osteoarthritis: current thoughts; Ther Adv Musculoskel Dis 1-14, Volume: 9 issue: 8, page(s): 183–196, DOI: 10.1177/ 1759720X16642405, 2016
  2. Evans CH et al.: Autologous Conditioned Serum. Phys Med Rehabil Clin N Am 27 (2016) 893–908
  3. Godek P: Use of Autologous Serum in Treatment of Lumbar Radiculopathy Pain. Pilot Study. Ortopedia Traumatologia Rehabilitacja, MEDSPORTPRESS, 2016; 1(6); Vol. 18, 11-20 DOI: 10.5604/15093492.1198829
  4. Richards MM et al.: Intra-articular treatment of knee osteoarthritis: from anti-inflammatories to products of regenerative medicine. Phys Sportsmed. 2016; 44(2):101-8. doi: 10.1080/00913847.2016.1168272. Epub 2016 Apr 4. Review. PubMed PMID: 26985986; PubMed Central PMCID: PMC4932822
  1. Pecin M et al.: Accelerated Achilles tendon healing with interleukin-1 receptor antagonist protein in rabbits. Turk J Vet Anim Sci, (2017) 41: 118-126; TÜBİTAK doi:10.3906/vet-1604-32
  2. Arbel R: Bio-orthopaedics: A new approach. ORTHOKINE. In A. Gobbi, J. G. Lane, J. Espregueira-Mendes, & M. Karahan (Eds.), Bio-orthopaedics: A New Approach (pp. 1–696). ISAKOS. http://doi. org/10.1007/978-3-662-54181-4
  3. Caggiari G et al.: Chondroprotective Effects of Intra-Articular Autologous Conditioned Serum (ACS) Injection A Human Literature. International Journal of Innovative Science, Engineering & Technology, 4(3), 289–293
  4. Strümper R: Intra-Articular Injections of Autologous Conditioned Serum to Treat Pain from Meniscal Lesions, Sports Medicine International Open 2017; 1: E200–E205
  5. Wehling P et al.: Effectiveness of intra-articular therapies in osteoarthritis: a literature review; Ther Adv Musculoskel Dis 1-14: https://doi.org/10.1177/1759720X17712695, 2017
  1. Tassara M et al.: Autologous conditioned serum (ACS) for intra-articular treatment in Osteoarthritis: retrospective report of 28 cases. Transfusion and Apheresis Science. http://doi.org/10.1016/j.transci. 2018.07.021
  2. Damjanov N et al.: The efficacy and safety of autologous conditioned serum (ACS) injections compared with betamethasone and placebo injections in the treatment of chronic shoulder joint pain due to supraspinatus tendinopathy: a prospective, randomized, double-blind, controlled study. Med Ultrason (2018), 1-7, DOI: 10.11152/mu-1495
  3. Genç E et al.: Investigation of the biomechanical and histopathological effects of autologous conditioned serum on healing of Achilles tendon. Acta Orthop Traumatol Turc, 1–6. http://doi.org/10.1016/j. aott.2018.01.005