Science & Media Publications

Publikationen 2016–2018


54. Tassara M et al.: Autologous conditioned serum (ACS) for intra-articular treatment in Osteoarthritis: retrospective report of 28 cases. Transfusion and Apheresis Science. 2018.07.021
53. Damjanov N et al.: The efficacy and safety of autologous conditioned serum (ACS) injections compared with betamethasone and placebo injections in the treatment of chronic shoulder joint pain due to supraspinatus tendinopathy: a prospective, randomized, double-blind, controlled study. Med Ultrason (2018), 1-7, DOI: 10.11152/mu-1495
52. Genç E et al.: Investigation of the biomechanical and histopathological effects of autologous conditioned serum on healing of Achilles tendon. Acta Orthop Traumatol Turc, 1–6. aott.2018.01.005


51. Pecin M et al.: Accelerated Achilles tendon healing with interleukin-1 receptor antagonist protein in rabbits. Turk J Vet Anim Sci, (2017) 41: 118-126; TÜBİTAK doi:10.3906/vet-1604-32
50. Arbel R: Bio-orthopaedics: A new approach. ORTHOKINE. In A. Gobbi, J. G. Lane, J. Espregueira-Mendes, & M. Karahan (Eds.), Bio-orthopaedics: A New Approach (pp. 1–696). ISAKOS. http://doi. org/10.1007/978-3-662-54181-4
49. Caggiari G et al.: Chondroprotective Effects of Intra-Articular Autologous Conditioned Serum (ACS) Injection A Human Literature. International Journal of Innovative Science, Engineering & Technology, 4(3), 289–293
48. Strümper R: Intra-Articular Injections of Autologous Conditioned Serum to Treat Pain from Meniscal Lesions, Sports Medicine International Open 2017; 1: E200–E205
47. Wehling P et al.: Effectiveness of intra-articular therapies in osteoarthritis: a literature review; Ther Adv Musculoskel Dis 1-14:, 2017


46. Wehling P et al: How does surgery compare with advanced intra-articular therapies in knee osteoarthritis: current thoughts; Ther Adv Musculoskel Dis 1-14, Volume: 9 issue: 8, page(s): 183–196, DOI: 10.1177/ 1759720X16642405, 2016
45. Evans CH et al.: Autologous Conditioned Serum. Phys Med Rehabil Clin N Am 27 (2016) 893–908
44. Godek P: Use of Autologous Serum in Treatment of Lumbar Radiculopathy Pain. Pilot Study. Ortopedia Traumatologia Rehabilitacja, MEDSPORTPRESS, 2016; 1(6); Vol. 18, 11-20 DOI: 10.5604/15093492.1198829
43. Richards MM et al.: Intra-articular treatment of knee osteoarthritis: from anti-inflammatories to products of regenerative medicine. Phys Sportsmed. 2016; 44(2):101-8. doi: 10.1080/00913847.2016.1168272. Epub 2016 Apr 4. Review. PubMed PMID: 26985986; PubMed Central PMCID: PMC4932822

Publikationen 2011–2015


42. Frisbie DD: Autologous-conditioned serum: evidence for use in the knee. J Knee Surg. 2015 Feb; 28(1):63-6. doi: 10.1055/s-0034-1543956. Epub 2015 Jan 19. PubMed PMID: 25599270
41. Baselga J et al: Treatment of Osteoarthritis of the Knee with a Combination of Autologous Conditioned Serum and Physiotherapy: A Two-Year Observational Study. PLoS ONE 10(12): e0145551.
40. Geburek F et al.: Effect of a single injection of autologous conditioned serum (ACS) on tendon healing in equine naturally occurring tendinopathies; Stem Cell Research & Therapy 6:126 (2015)
39. Torrero JI, Martínez C: New developments in the treatment of osteoarthritis -focus on biologic agents. Open Access Rheumatol. 2015 Jul 22;7:33-43. eCollection 2015. Review. PubMed PMID: 27790043; PubMed Central PMCID: PMC5045124.


38. Astolfi M, McGuire K, Kaminski TW: The effectiveness of autologous conditioned serum in the treatment of knee osteoarthritis. J Sport Rehabil. 2014 Nov;23(4):365-9. doi: 10.1123/jsr.2013-0029. Epub 2014 May 2. Review. PubMed PMID: 24810293.
37. Beyzadeoglu T: Cytokines in Sports Medicine. ISAKOS NEWSLETTER 2014: Volume I. Current Concepts, 1–44.
36. Majewski M, von Wehren L, & Blanke F: Treatment Of Achillodynia With Local Injections Of Autologous Conditioned Serum (acs). British Journal of Sports Medicine, 48(Suppl_2), A38–A39.


35. Alvarez-Camino JC et al.: Use of autologous conditioned serum (ORTHOKINE) for the treatment of the degenerative osteoarthritis of the temporomandibular joint. Review of the literature. Med Oral Patol Oral Cir Bucal (2013) 18 (3): 433–438
34. Frizziero A et al.: Autologous conditioned serum for the treatment of osteoarthritis and other possible applications in musculoskeletal disorders. Br Med Bull (2013) 105: 169–184
33. Baltzer AWA et al.: A new treatment for hip osteoarthritis: clinical evidence for the efficacy of autologous conditioned serum. Orthop Rev (2013) 5(2):e13
32. Weisshaar MP, Gaji S: Signaling Proteins (Growth Factors and Cytokines) in Orthopaedics. Comparison of two blood processing techniques: ORTHOKINE® and ACP®. CORS congress 2013 Venice, Italy
31. Morgenstern DR et al.: Adjunctive Biological Treatment for Degenerative Hip Disease with Focal Chondro Labral Defects. ISHA Annual Meeting, Munich, Poster 58 (2013)


30. Heisterbach PE et al.: Effect of BMP-12, TGF-β1 and autologous conditioned serum on growth factor expression in Achilles tendon healing. Knee Surg Sports Traumatol Arthrosc (2012) 20(10): 1907–1914


29. Textor J: Autologous biologic treatment for equine musculoskeletal injuries: platelet-rich plasma and IL-1 receptor antagonist protein. Vet Clin North Am Equine Pract. 2011 Aug; 27(2): 275–298. doi: 10.1016/j.cveq.2011.05.001. PubMed PMID: 21872759
28. Darabos N et al.: Intraarticular application of autologous conditioned serum (ACS) reduces bone tunnel widening after ACL reconstructive surgery in a randomized controlled trial. Knee Surg Sports Traumatol Arthrosc (2011) 19: 36–46
27. Geburek F, Stadler P: Regenerative therapy for tendon and ligament disorders in horses. Terminology, production, biologic potential and in vitro effects. Tierarztl Prax Ausg G Grosstiere Nutztiere. 2011; 39(6): 373–83. Review. German. PubMed PMID: 22167082

Publikationen 2008–2010


26. Fox BA, Stephens MM: Treatment of knee osteoarthritis with ORTHOKINE-derived autologous conditioned serum. Expert Rev Clin Immunol (2010) 6(3): 335–345


25. Wehling P et al.: Use of Autologous Conditioned Cell-free Serum (ORTHOKINE®) in Treating Osteoarthritis and Sciatic Back Pain. European Musculoskeletal Review (2009) 4(1): 8–11
24. Majewski M et al.: Accelerated Healing of the Rat Achilles Tendon in Response to Autologous Conditioned Serum. The American Journal of Sports Medicine (2009) 11: 2117–2125
23. Chevalier X et al.: Intraarticular injection of anakinra in osteoarthritis of the knee: a multicenter, randomized, double-blind, placebo-controlled study. Arthritis & Rheumatism (2009) 61(3): 344–352
22. Baltzer AWA et al.: Autologous conditioned serum (ORTHOKINE®) is an effective treatment for knee osteoarthritis. Osteoarthritis and Cartilage (2009) 17(2): 152–160
21. Darabos N et al.: Correlation between synovial fluid and serum IL-1ß levels after ACL surgery - preliminary report. International Orthopedics (SICOT) (2009) 33: 413–418



20. Yang KG et al.: Autologous interleukin-1 receptor antagonist improves function and symptoms in osteoarthritis when compared to placebo in a prospective randomized controlled trial. Osteoarthritis and Cartilage (2008) 16(4): 498–505
19. Österdahl J: Evaluation of autologous conditioned serum. Degree project 2008:67 at Swedish University of Agricultural Sciences, Uppsala (2008) ISSN 1652-8697
18. Creaney L, Hamilton B: Growth factor delivery methods in the management of sports injuries: the state of play. Br J Sports Med (2008) 42: 314–320
17. Jöstingmeier U: Vergleichende Betrachtung des Behandlungserfolges der intra-artikulären kombinierten Behandlung mit Natriumhyaluronat und Betamethason mit der intraartikulären Behandlung mit autologem konditionierten Serum (IL-1Ra) bei Pferden mit positiver Hufgelenksanästhesie - Eine Anwendungsbeobachtung. In-augural-Dissertation an der Freien Universität Berlin (2008) ISBN 978-3-86664-665-0
16. Martinelli MJ et al.: Biochemical Characterization and Clinical Assessment of Autologous Conditioned Serum Treatment in Race Horses. Annual Meeting of the Orthopaedic Research Society 2008, San Francisco, USA
15. Weinberger T: Klinische Erfahrungen mit der Anwendung von ACS / ORTHOKIN® / IRAP beim Pferd. pferde spiegel 3/2008
14. Weinberger T.: Clinical experience with ACS/ORTHOKINE/IRAP in horses. Equine Sports Medicine 3/2008
13. Weinberger T.: Regenerative Therapiemöglichkeiten beim Pferd – eine Übersicht. pferde spiegel 3/2008


Publikationen 2003–2007


12. Becker C et al.: Efficacy of epidural perineural injections with autologous conditioned serum for lumbar radicular compression: an investigator-initiated, prospective, double-blind, reference-controlled study. Spine (2007) 32(17): 1803–1808
11. Frisbie DD et al.: Clinical, biochemical, and histologic effects of intra-articular administration of autologous conditioned serum in horses with experimentally induced osteoarthritis. Am J Vet Res (2007) 68(3): 290–296
10. Wehling P et al.: Autologous Conditioned Serum in the treatment of Orthopaedic diseases – The ORTHOKINE® Therapy. Biodrugs (2007) 21(5): 323–332


9. Glawe H: ORTHOKIN®-Therapie: Autologes Conditioniertes Serum an der Wirbelsäule. Eine Anwendungsbeobachtung an 261 Patienten. Poster 2006
8. Theodoridis T, Krämer J: Interleukin-1-Rezeptor-Antagonist-Protein (IRAP). In: Injektionstherapie an der Wirbelsäule. Manual und Atlas, 37-40. Georg Thieme Verlag (2006) ISBN 3-13-141041-8A



7. Moser C et al.: Die Rolle der Zytokine bei Knorpeldefekten und in der Knorpeltherapie. Interleukin-1 und TNF-a: Schlüsselfaktoren der Knorpeldestruktion. Arthroskopie (2005) 18(3): 181–185
6. Levy E et al.: Intraartikuläre Behandlung mit autologem irap conditionierten Serum – Teil 1. pferde spiegel 3/2005: 120–124
5. Hague BA: Clinical Impression of ORTHOKINE (IRAP) Treating Joint Disease in the Performance Horse. ACVS conference 2005, San Diego, USA


4. Wright-Carpenter T et al.: Treatment of muscle injuries by local administration of autologous conditioned serum: animal experiments using a muscle contusion model. Int J Sports Med (2004) 25(8): 582-587
3. Wright-Carpenter T et al.: Treatment of muscle injuries by local administration of autologous conditioned serum: a pilot study on sportsmen with muscle strains. Int J Sports Med (2004) 25(8): 588–593


2. Meijer H et al.: The production of anti-inflammatory cytokines in whole blood by physico-chemical induction. Inflamm Res (2003) 52(10): 404–407
1. Baltzer AWA et al: Intraartikuläre Therapie der Gonarthrose mit autologem Interleukin-1 Rezeptor Antagonisten (IL-1Ra). Deutsche Zeitschrift für Sportmedizin (2003) 54(6): 209–211